Donna Peehl, PhD's Publications

Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures.

The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor.

Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1.

miR-22 Regulates Invasion, Gene Expression and Predicts Overall Survival in Patients with Clear Cell Renal Cell Carcinoma.

NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose.

S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma.

A note on improved statistical approaches to account for pseudoprogression.

A spliced form of CD44 expresses the unique glycan that is recognized by the prostate cancer specific antibody F77.

Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics.

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.

The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry.

A Protective Role for Androgen Receptor in Clear Cell Renal Cell Carcinoma Based on Mining TCGA Data.

Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation.

Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer.

Endoscopic detection of cancer with lensless radioluminescence imaging and machine vision.

Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance.

Rockets, radiosensitizers, and RRx-001: an origin story part I.

RRx-001, A novel dinitroazetidine radiosensitizer.

Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer.

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism.

A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity.

Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer.

Elevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort.

Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity.

Hepcidin regulation in prostate and its disruption in prostate cancer.

Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor.

NO to cancer: The complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001.

Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001.

Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study.

Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array.

Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes.

Development of a realistic in vivo bone metastasis model of human renal cell carcinoma.

Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma.

Phosphorylcholine-coated semiconducting polymer nanoparticles as rapid and efficient labeling agents for in vivo cell tracking.

Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype.

A tissue graft model of DNA damage response in the normal and malignant human prostate.

Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer.

Establishment and serial passage of cell cultures derived from LuCaP xenografts.

Imaging the glycosylation state of cell surface glycoproteins by two-photon fluorescence lifetime imaging microscopy.

Induced pluripotency of human prostatic epithelial cells.

Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor.

Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate.

Patient-derived tissue slice grafts accurately depict response of high-risk primary prostate cancer to androgen deprivation therapy.

Preclinical trial of a new dual mTOR inhibitor, MLN0128, using renal cell carcinoma tumorgrafts.

Radioprotection and cell cycle arrest of intestinal epithelial cells by darinaparsin, a tumor radiosensitizer.

Tissue slice grafts of human renal cell carcinoma: an authentic preclinical model with high engraftment rate and metastatic potential.

Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation.

Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer.

Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes.

Microfluidic integration for automated targeted proteomic assays.

Suppression of Tak1 promotes prostate tumorigenesis.

Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progression.

Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells.

DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer.

Serum Mac-2BP does not distinguish men with high grade, large volume prostate cancer from men with benign prostatic hyperplasia.

Stiffness mapping prostate biopsy samples using a tactile sensor.

The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin.

Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status.

Metalloporphyrin synergizes with ascorbic acid to inhibit cancer cell growth through fenton chemistry.

Targeting monoamine oxidase A in advanced prostate cancer.

Tissue slice grafts: an in vivo model of human prostate androgen signaling.

Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells.

Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients.

Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate.

The elevated expression of a mismatch repair protein is a predictor for biochemical recurrence after radical prostatectomy.

Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts.

Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer.

Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.

Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells.

The current state of preclinical prostate cancer animal models.

The significance of monoamine oxidase-A expression in high grade prostate cancer.

Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level.

Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer.

Calcitriol as a chemopreventive and therapeutic agent in prostate cancer: role of anti-inflammatory activity.

Distinctive gene expression of prostatic stromal cells cultured from diseased versus normal tissues.

High resolution regional elasticity mapping of the human prostate.

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement.

Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer.

Potentiation of the growth-inhibitory effects of vitamin D in prostate cancer by genistein.

Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer.

Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors.

Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells.

Expression of CCL5 (RANTES) and CCR5 in prostate cancer.

Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D.

Mechanisms of vitamin D-mediated growth inhibition in prostate cancer cells: inhibition of the prostaglandin pathway.

Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer.

Tumor-selective killing by selenite in patient-matched pairs of normal and malignant prostate cells.

Tumor-suppression function of transcription factor USF2 in prostate carcinogenesis.

Comparative gene and protein expression in primary cultures of epithelial cells from benign prostatic hyperplasia and prostate cancer.

Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity.

Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease.

Molecular targets of doxazosin in human prostatic stromal cells.

Preferential production of latent transforming growth factor beta-2 by primary prostatic epithelial cells and its activation by prostate-specific antigen.

Primary cell cultures as models of prostate cancer development.

Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing.

Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells.

Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells.

Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays.

Are primary cultures realistic models of prostate cancer?

CXCR4 and CXCL12 (SDF-1) in prostate cancer: inhibitory effects of human single chain Fv antibodies.

Elevated expression of inhibin alpha in prostate cancer.

Epigenetic repression of transcription by the Vitamin D3 receptor in prostate cancer cells.

Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts.

Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer.

Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells.

Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis.

Molecular and cellular pathogenesis of benign prostatic hyperplasia.

Re-evaluation of inhibin alpha subunit as a tumour suppressor in prostate cancer.

Elevated expression of inhibitor of apoptosis proteins in prostate cancer.

Growth of prostatic epithelial and stromal cells in vitro.

Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.

Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression.

Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line.

Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells.

Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase.

Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer.

Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells.

The role of vitamin D and retinoids in controlling prostate cancer progression.

The role of vitamin D in prostate cancer.

Vitamin D receptor start codon polymorphism (FokI) and prostate cancer progression.

A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer.

Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.

Cadmium-induced neoplastic transformation of human prostate epithelial cells.

Expression of matrix metalloproteinase-2 and -9 and their inhibitors, tissue inhibitor of metalloproteinase-1 and -2, in primary cultures of human prostatic stromal and epithelial cells.

Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis.

Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells.

Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens.

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line.

Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells.

Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway.

Characterization of cultured human prostatic epithelial cells by cluster designation antigen expression.

Genetic polymorphisms in the androgen receptor and type II 5 alpha-reductase genes in prostate enlargement.

Overview consensus statement.

Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation.

Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer.

Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition.

SMAD3 represses androgen receptor-mediated transcription.

1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell growth by androgen-dependent and androgen-independent mechanisms.

Brefeldin A induces p53-independent apoptosis in primary cultures of human prostatic cancer cells.

Cultured stromal cells: an in vitro model of prostatic mesenchymal biology.

Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia.

Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor.

p16INK4A mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells.

Stepwise genetic changes associated with progression of nontumorigenic HPV-18 immortalized human prostate cancer-derived cell line to a malignant phenotype.

Transforming growth factor-beta induces growth inhibition and IGF-binding protein-3 production in prostatic stromal cells: abnormalities in cells cultured from benign prostatic hyperplasia tissues.

Altered growth regulation and loss of response to retinoic acid accompany tumorigenic transformation of prostatic cells.

Induction of androgen receptor by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in LNCaP human prostate cancer cells.

Two mutations identified in the androgen receptor of the new human prostate cancer cell line MDA PCa 2a.

Vitamin D and prostate cancer risk.

Basic FGF, EGF, and PDGF modify TGFbeta-induction of smooth muscle cell phenotype in human prostatic stromal cells.

Defined medium for normal adult human prostatic stromal cells.

Expression of prostatic factors measured by reverse transcription polymerase chain reaction in human papillomavirus type 18 deoxyribonucleic acid immortalized prostate cell lines.

Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia.

Workgroup 2: human xenograft models of prostate cancer.

1alpha,25-dihydroxyvitamin D3 actions in LNCaP human prostate cancer cells are androgen-dependent.

Acid-activated insulin-like growth factor binding protein protease activity of cathepsin D in normal and malignant prostatic epithelial cells and seminal plasma.

Decreased expression of Wilms' tumor gene WT-1 and elevated expression of insulin growth factor-II (IGF-II) and type 1 IGF receptor genes in prostatic stromal cells from patients with benign prostatic hyperplasia.

Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution.

Human papillomavirus detection by polymerase chain reaction in benign and malignant prostate tissue is dependent on the primer set utilized.

Induction of smooth muscle cell phenotype in cultured human prostatic stromal cells.

Loss of response to epidermal growth factor and retinoic acid accompanies the transformation of human prostatic epithelial cells to tumorigenicity with v-Ki-ras.

Parathyroid hormone-related protein is not an autocrine growth factor for normal prostatic epithelial cells.

Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions.

7S nerve growth factor is an insulin-like growth factor-binding protein protease.

Cellular biology of prostatic growth factors.

Human prostatic epithelial and stromal cell lines and strains.

Keratin 19 in the adult human prostate: tissue and cell culture studies.

KGF and EGF differentially regulate the phenotype of prostatic epithelial cells.

Parathyroid hormone--related protein (PTHrP) is an epidermal growth factor-regulated secretory product of human prostatic epithelial cells.

Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts.

Recent advances in the development of animal and cell culture models for prostate cancer research A minireview.

Role of prostatic basal cells in the regulation and suppression of human prostate cancer cells.

Simian virus 40-, but not human papillomavirus-, transformation of prostatic epithelial cells results in loss of growth-inhibition by 1,25-dihydroxyvitamin D-3.

The role of insulin-like growth factors in prostate biology.

The role of the Sertoli cell in active immunosuppression in the human testis.

Actions of vitamin D3, analogs on human prostate cancer cell lines: comparison with 1,25-dihydroxyvitamin D3.

Altered growth-regulation of prostatic epithelial-cells by human papillomavirus-induced transformation.

Attenuated response of p53 and p21 in primary cultures of human prostatic epithelial cells exposed to DNA-damaging agents.

Keratinocyte growth factor: an androgen-regulated mediator of stromal-epithelial interactions in the prostate.

Suramin, hydrocortisone, and retinoic acid modify inhibitory effects of 1,25-dihydroxyvitamin D(3) on prostatic epithelial cells.

The insulin-like growth factor system in the prostate.

Vitamin D and prostate cancer.

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells.

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease.

Characterization of adult human prostatic epithelial-cells immortalized by polybrene-induced DNA transfection with a plasmid containing an origin-defective sv40-genome.

Human papilloma virus type 18 DNA immortalized cell lines from the human prostate epithelium.

Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients.

Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia.

Keratin expression: a measure of phenotypic modulation of human prostatic epithelial cells by growth inhibitory factors.

Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18 DNA.

The IGF axis in the prostate.

Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients.

Oncogenes in prostate cancer. An update.

PR1--a monoclonal antibody that reacts with an antigen on the surface of normal and malignant prostate cells.

Vitamin A regulates proliferation and differentiation of human prostatic epithelial cells.

Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines.

Analysis of prostatic tumor cultures using fluorescence in-situ hybridization (FISH).

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

Culture of prostatic epithelial cells from ultrasound-guided needle biopsies.

Cytogenetic evaluation of 20 cultured primary prostatic tumors.

Cytostatic effects of suramin on prostate cancer cells cultured from primary tumors.

In vitro proton spectroscopy of normal and abnormal prostate.

Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells.

Searching for suppressor genes in prostate cancer.

Analysis of somatic cell hybrids derived from normal human prostatic epithelial cells fused with HeLa cells.

Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells.

Frequency and pattern of karyotypic abnormalities in human prostate cancer.

Clonal growth of human prostatic epithelial cells is stimulated by fibroblasts.

In vitro studies of human prostatic epithelial cells: attempts to identify distinguishing features of malignant cells.

Transformation of human neonatal prostate epithelial cells by strontium phosphate transfection with a plasmid containing SV40 early region genes.

Clonal growth characteristics of adult human prostatic epithelial cells.

Activated Ki-ras oncogene in human prostatic adenocarcinoma.

Oncogene expression.

Growth responses of normal, benign hyperplastic, and malignant human prostatic epithelial cells in vitro to cholera toxin, pituitary extract, and hydrocortisone.

Oncogenes: a review with relevance to cancers of the urogenital tract.

Serum-free growth of adult human prostatic epithelial cells.

Keratin immunoreactivity in the benign and neoplastic human prostate.

Serial propagation of adult human prostatic epithelial cells with cholera toxin.

Human cell hybrids: analysis of transformation and tumorigenicity.

The role of differentiation in the suppression of tumorigenicity in human cell hybrids.

Characterization of human keratinocyte X HeLa somatic cell hybrids.

Clonal growth of human keratinocytes with small amounts of dialyzed serum.

Growth and differentiation of human keratinocytes without a feeder layer or conditioned medium.