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John Lynch, PhD
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Publications
John Lynch, PhD's Publications
Comparison of definitions of early knee osteoarthritis for likelihood of progression at 2-year and 5-year follow-up: the Multicenter Osteoarthritis Study.
Diagnostic value of MRI for detection of knee cartilage lesions vs. weight-bearing CT arthrography (WBCTa).
Does hsCRP provide insights into an inflammatory phenotype of knee osteoarthritis?
Gender-differences in imaging phenotypes of osteoarthritis in the osteoarthritis initiative.
Intra-articular Knee Injections and Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.
MRI-based analysis of thigh intramuscular fat and its associations with age, sex, and BMI using data from the osteoarthritis initiative data.
Quantifying knee-adjacent subcutaneous fat in the entire OAI baseline dataset - Associations with cartilage MRI T2, thickness and pain, independent of BMI.
Synovitis mediates cartilage outcomes during weight-loss in knee osteoarthritis - 4-year follow-up data from the Osteoarthritis Initiative.
The relation of walking forces to structural damage in the knee: The Multicenter Osteoarthritis Study.
Thigh-muscle volume change in response to diet, exercise, and weight-loss in overweight and obese individuals-8-year follow-up data from the Osteoarthritis Initiative.
Ultra-processed food consumption is associated with knee osteoarthritis: Data from the Osteoarthritis Initiative.
Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years: An individual participant data meta-analysis of 18,807 hips from the World COACH consortium.
Assessing the association of epigenetic age acceleration with osteoarthritis in the Multicenter Osteoarthritis Study (MOST).
Clinical and imaging findings associated with preservation of knee joint health over 8 years in individuals aged 65 and over: data from the OAI.
Cohort profile: Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH) - an international consortium of prospective cohort studies with individual participant data on hip osteoarthritis.
Comparison of definitions of early knee osteoarthritis for likelihood of progression at 2-year and 5-year follow-up: the Multicenter Osteoarthritis Study.
Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative.
Thigh muscle and fat volumes are associated with knee cartilage abnormalities and bone marrow edema-like lesions: data from the osteoarthritis initiative.
Association of Medial Meniscus Root Tears and Nonroot Tears With Worsening of Radiographic Knee Osteoarthritis.
Associations between weight change, knee subcutaneous fat and cartilage thickness in overweight and obese individuals: 4-Year data from the osteoarthritis initiative.
Prevalence of intra-articular mineralization on knee computed tomography: the multicenter osteoarthritis study.
Do associations with hand OA vary by knee osteoarthritis phenotype? Cross-sectional data from the Multicenter Osteoarthritis Study.
Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative.
Impact of Sustained Synovitis on Knee Joint Structural Degeneration: 4-Year MRI Data from the Osteoarthritis Initiative.
Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis.
Multiparametric 3-D analysis of bone and joint space width at the knee from weight bearing computed tomography.
Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.
Bone Structure Analysis of the Radius Using Ultrahigh Field (7T) MRI: Relevance of Technical Parameters and Comparison with 3T MRI and Radiography.
Clinical value of weight-bearing CT and radiographs for detecting patellofemoral cartilage visualized by MRI in the MOST study.
Cross-sectional and longitudinal reliability of semiquantitative osteoarthritis assessment at 1.0T extremity MRI: Multi-reader data from the MOST study.
Longitudinal Relationship Between Tibiofemoral Contact Stress at Baseline and Worsening of Knee Pain Over 84 Months in the Multicenter Osteoarthritis Study.
Magnetic Resonance Imaging-Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: Data From the Multicenter Osteoarthritis Study.
Opioid users show worse baseline knee osteoarthritis and faster progression of degenerative changes: a retrospective case-control study based on data from the Osteoarthritis Initiative (OAI).
Quantitative Three-dimensional Assessment of Knee Joint Space Width from Weight-bearing CT.
Weight Cycling and Knee Joint Degeneration in Individuals with Overweight or Obesity: Four-Year Magnetic Resonance Imaging Data from the Osteoarthritis Initiative.
Associations Between Vitamins C and D Intake and Cartilage Composition and Knee Joint Morphology Over 4 Years: Data From the Osteoarthritis Initiative.
Natural history of new horizontal meniscal tears in individuals at risk for and with mild to moderate osteoarthritis: data from osteoarthritis initiative.
Patterns of Change Over Time in Knee Bone Shape Are Associated with Sex.
Predictive value of the morphology of proximal tibiofibular joint for total knee replacement in patients with knee osteoarthritis.
Reliability of a new scoring system for intraarticular mineralization of the knee: Boston University Calcium Knee Score (BUCKS).
Varus alignment of the proximal tibia is associated with structural progression in early to moderate varus osteoarthritis of the knee.
A pilot study of peripheral blood DNA methylation models as predictors of knee osteoarthritis radiographic progression: data from the Osteoarthritis Initiative (OAI).
MRI-based screening for structural definition of eligibility in clinical DMOAD trials: Rapid OsteoArthritis MRI Eligibility Score (ROAMES).
The morphology of proximal tibiofibular joint (PTFJ) predicts incident radiographic osteoarthritis: data from Osteoarthritis Initiative.
The Relationship of Three-Dimensional Joint Space Width on Weight Bearing CT With Pain and Physical Function.
Associations between molecular biomarkers and MR-based cartilage composition and knee joint morphology: data from the Osteoarthritis Initiative.
Bone shape mediates the relationship between sex and incident knee osteoarthritis.
Periarticular bone predicts knee osteoarthritis progression: Data from the Osteoarthritis Initiative.
Quantitative measurement of cartilage volume is possible using two-dimensional magnetic resonance imaging data sets.
Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the Osteoarthritis Initiative.
Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study.
Quantitative measurement of medial femoral knee cartilage volume - analysis of the OA Biomarkers Consortium FNIH Study cohort.
Relationship of Trochlear Morphology and Patellofemoral Joint Alignment to Superolateral Hoffa Fat Pad Edema on MR Images in Individuals with or at Risk for Osteoarthritis of the Knee: The MOST Study.
Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: Data from the osteoarthritis initiative.
Baseline trabecular bone and its relation to incident radiographic knee osteoarthritis and increase in joint space narrowing score: directional fractal signature analysis in the MOST study.
Defining and evaluating a novel outcome measure representing end-stage knee osteoarthritis: data from the Osteoarthritis Initiative.
Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative.
Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease - data from the Osteoarthritis Initiat
Relation of Step Length to Magnetic Resonance Imaging-Detected Structural Damage in the Patellofemoral Joint: The Multicenter Osteoarthritis Study.
Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change.
Semiquantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.
The association of distal femur and proximal tibia shape with sex: The Osteoarthritis Initiative.
The relationship between meniscal pathology and osteoarthritis depends on the type of meniscal damage visible on magnetic resonance images: data from the Osteoarthritis Initiative.
A reference database of cartilage 3 T MRI T2 values in knees without diagnostic evidence of cartilage degeneration: data from the osteoarthritis initiative.
Association of cartilage degeneration with four year weight gain--3T MRI data from the Osteoarthritis Initiative.
Association of Physical Activity Measured by Accelerometer, Knee Joint Abnormalities, and Cartilage T2 Measurements Obtained From 3T Magnetic Resonance Imaging: Data From the Osteoarthritis Initiative.
Brief Report: Cartilage Thickness Change as an Imaging Biomarker of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.
Diagnostic performance of 3D standing CT imaging for detection of knee osteoarthritis features.
Diagnostic performance of 3D standing CT imaging for detection of knee osteoarthritis features.
Do persons with asymmetric hip pain or radiographic hip OA have worse pain and structure outcomes in the knee opposite the more affected hip? Data from the Osteoarthritis Initiative.
Knee joint subchondral bone structure alterations in active athletes: a cross-sectional case-control study.
Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium.
Multi-dimensional reliability assessment of fractal signature analysis in an outpatient sports medicine population.
Novel statistical methodology reveals that hip shape is associated with incident radiographic hip osteoarthritis among African American women.
Severe radiographic knee osteoarthritis--does Kellgren and Lawrence grade 4 represent end stage disease?--the MOST study.
Validity and sensitivity to change of three scales for the radiographic assessment of knee osteoarthritis using images from the Multicenter Osteoarthritis Study (MOST).
Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project.
A new method to measure anatomic knee alignment for large studies of OA: data from the osteoarthritis initiative.
Association of hip and pelvic geometry with tibiofemoral osteoarthritis: multicenter osteoarthritis study (MOST).
Association of incident symptomatic hip osteoarthritis with differences in hip shape by active shape modeling: the Johnston County Osteoarthritis Project.
Cartilage lesion score: comparison of a quantitative assessment score with established semiquantitative MR scoring systems.
CT imaging for evaluation of calcium crystal deposition in the knee: initial experience from the Multicenter Osteoarthritis (MOST) study.
Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative.
Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing in persons with knee OA--the MOST study.
Proximal femur shape differs between subjects with lateral and medial knee osteoarthritis and controls: the Osteoarthritis Initiative.
Scoring hip osteoarthritis with MRI (SHOMRI): A whole joint osteoarthritis evaluation system.
Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: the MOST study.
Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative.
Association between measures of patella height, morphologic features of the trochlea, and patellofemoral joint alignment: the MOST study.
Association of frequent knee bending activity with focal knee lesions detected with 3T magnetic resonance imaging: data from the osteoarthritis initiative.
Association of metabolic risk factors with cartilage degradation assessed by T2 relaxation time at the knee: data from the osteoarthritis initiative.
Association of trochlear dysplasia with degenerative abnormalities in the knee: data from the Osteoarthritis Initiative.
Bone marrow lesion volume reduction is not associated with improvement of other periarticular bone measures: data from the Osteoarthritis Initiative.
Correlation of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with body mass index: thirty-six-month followup data from a longitudinal, observational multicenter study.
Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker--longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative.
Focal knee lesions in knee pairs of asymptomatic and symptomatic subjects with OA risk factors--data from the Osteoarthritis Initiative.
Lateral and medial joint space narrowing predict subsequent cartilage loss in the narrowed, but not in the non-narrowed femorotibial compartment--data from the Osteoarthritis Initiative.
Medial posterior meniscal root tears are associated with development or worsening of medial tibiofemoral cartilage damage: the multicenter osteoarthritis study.
Physical activity in relation to knee cartilage T2 progression measured with 3 T MRI over a period of 4 years: data from the Osteoarthritis Initiative.
Quantification of bone marrow lesion volume and volume change using semi-automated segmentation: data from the osteoarthritis initiative.
T(2) relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur: longitudinal data from the osteoarthritis initiative.
Association of magnetic resonance imaging-based knee cartilage T2 measurements and focal knee lesions with knee pain: data from the Osteoarthritis Initiative.
Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3 years--data from the Osteoarthritis Initiative.
Bone marrow lesions are associated with altered trabecular morphometry.
Elevated tibiofemoral articular contact stress predicts risk for bone marrow lesions and cartilage damage at 30 months.
How do short-term rates of femorotibial cartilage change compare to long-term changes? Four year follow-up data from the osteoarthritis initiative.
Lumbosacral transitional vertebrae: association with low back pain.
Peripatellar synovitis: comparison between non-contrast-enhanced and contrast-enhanced MRI and association with pain. The MOST study.
Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint--the MOST study.
Prevalent cartilage damage and cartilage loss over time are associated with incident bone marrow lesions in the tibiofemoral compartments: the MOST study.
Reliability of semiautomated computational methods for estimating tibiofemoral contact stress in the Multicenter Osteoarthritis Study.
The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI--the MOST study.
The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study.
Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.
Active shape modeling of the hip in the prediction of incident hip fracture.
Association between measures of trochlear morphology and structural features of patellofemoral joint osteoarthritis on MRI: the MOST study.
Changes in knee cartilage T2 values over 24 months in subjects with and without risk factors for knee osteoarthritis and their association with focal knee lesions at baseline: data from the osteoarthritis initiative.
Obesity increases the prevalence and severity of focal knee abnormalities diagnosed using 3T MRI in middle-aged subjects--data from the Osteoarthritis Initiative.
Physical activity is associated with magnetic resonance imaging-based knee cartilage T2 measurements in asymptomatic subjects with and those without osteoarthritis risk factors.
Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study.
Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis.
Risk factors for medial meniscal pathology on knee MRI in older US adults: a multicentre prospective cohort study.
Texture analysis of cartilage T2 maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR T2 compared to normal controls--data from the osteoarthritis initiative.
Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study.
Association between patella alta and the prevalence and worsening of structural features of patellofemoral joint osteoarthritis: the multicenter osteoarthritis study.
Comparison of BLOKS and WORMS scoring systems part I. Cross sectional comparison of methods to assess cartilage morphology, meniscal damage and bone marrow lesions on knee MRI: data from the osteoarthritis initiative.
Comparison of BLOKS and WORMS scoring systems part II. Longitudinal assessment of knee MRIs for osteoarthritis and suggested approach based on their performance: data from the Osteoarthritis Initiative.
Cyst-like lesions of the knee joint and their relation to incident knee pain and development of radiographic osteoarthritis: the MOST study.
Does measurement of the anatomic axis consistently predict hip-knee-ankle angle (HKA) for knee alignment studies in osteoarthritis? Analysis of long limb radiographs from the multicenter osteoarthritis (MOST) study.
Implementation of discrete element analysis for subject-specific, population-wide investigations of habitual contact stress exposure.
Longitudinal analysis of MRI T(2) knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative.
Longitudinal analysis of MRI T2 knee cartilage laminar organization in a subset of patients from the osteoarthritis initiative: a texture approach.
Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study.
Subchondral cystlike lesions develop longitudinally in areas of bone marrow edema-like lesions in patients with or at risk for knee osteoarthritis: detection with MR imaging--the MOST study.
Subjects with higher physical activity levels have more severe focal knee lesions diagnosed with 3T MRI: analysis of a non-symptomatic cohort of the osteoarthritis initiative.
Varus and valgus alignment and incident and progressive knee osteoarthritis.
Vastus lateralis/vastus medialis cross-sectional area ratio impacts presence and degree of knee joint abnormalities and cartilage T2 determined with 3T MRI - an analysis from the incidence cohort of the Osteoarthritis Initiative.
A comparison of dedicated 1.0 T extremity MRI vs large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study.
Baseline articular contact stress levels predict incident symptomatic knee osteoarthritis development in the MOST cohort.
Cartilage loss occurs in the same subregions as subchondral bone attrition: a within-knee subregion-matched approach from the Multicenter Osteoarthritis Study.
Contrast-enhanced MRI of subchondral cysts in patients with or at risk for knee osteoarthritis: the MOST study.
Patellar cartilage: T2 values and morphologic abnormalities at 3.0-T MR imaging in relation to physical activity in asymptomatic subjects from the osteoarthritis initiative.
Pre-radiographic MRI findings are associated with onset of knee symptoms: the most study.
Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study.
The association of proximal femoral shape and incident radiographic hip OA in elderly women.
Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the multicenter osteoarthritis study.
Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis.
Strong association of MRI meniscal derangement and bone marrow lesions in knee osteoarthritis: data from the osteoarthritis initiative.
The association of meniscal damage with joint effusion in persons without radiographic osteoarthritis: the Framingham and MOST osteoarthritis studies.
Effect of meniscal damage on the development of frequent knee pain, aching, or stiffness.
Micro-CT arthrography: a pilot study for the ex vivo visualization of the rat knee joint.
Short tau inversion recovery and proton density-weighted fat suppressed sequences for the evaluation of osteoarthritis of the knee with a 1.0 T dedicated extremity MRI: development of a time-efficient sequence protocol.
Femoral neck trabecular microstructure in ovariectomized ewes treated with calcitonin: MRI microscopic evaluation.
Imaging of bone erosion in rheumatoid arthritis.
Measurement of changes in trabecular bone at fracture sites using X-ray CT and automated image registration and processing.
Micro-CT of carotid arteries: a tool for experimental studies.
Multispectral analysis of bone lesions in the hands of patients with rheumatoid arthritis.
Quantification of bone lesions in rheumatoid arthritis by MRI multispectral tissue class transition analysis.
Rheumatoid arthritis of the hand and wrist: comparison of three imaging techniques.
Use of multispectral magnetic resonance imaging analysis to quantify erosive changes in the hands of patients with rheumatoid arthritis: short-term and long-term longitudinal studies.
Comparison of fixed-flexion positioning with fluoroscopic semi-flexed positioning for quantifying radiographic joint-space width in the knee: test-retest reproducibility.
Digital tomosynthesis of hand joints for arthritis assessment.
Quantitative and qualitative assessment of closed fracture healing using computed tomography and conventional radiography.
Value of micro-CT as an investigative tool for osteochondritis dissecans.
A comparison of two nickel-titanium instrumentation techniques in teeth using microcomputed tomography.
Early radiographic features in patients with anterior cruciate ligament rupture.
Field test of the reproducibility of automated measurements of medial tibiofemoral joint space width derived from standardized knee radiographs.
Micro-computed tomography: a new tool for experimental endodontology.
Fractal signature analysis measures cancellous bone organisation in macroradiographs of patients with knee osteoarthritis.
Microfocal techniques in quantitative radiography: measurement of cancellous bone organization.
Joint space width measures cartilage thickness in osteoarthritis of the knee: high resolution plain film and double contrast macroradiographic investigation.
Quantitative microfocal radiography detects changes in OA knee joint space width in patients in placebo controlled trial of NSAID therapy.
Sensitivity of radiographic features and specificity of scintigraphic imaging in hand osteoarthritis.
Fractal signature analysis of macroradiographs measures trabecular organization in lumbar vertebrae of postmenopausal women.
Quantitative microfocal radiographic assessment of osteoarthritis of the knee from weight bearing tunnel and semiflexed standing views.
A study of the early and late 99technetium scintigraphic images and their relationship to symptoms in osteoarthritis of the hands.
Microfocal radiography with macroradiographs in osteoarthritis.
Precision of joint space width measurement in knee osteoarthritis from digital image analysis of high definition macroradiographs.
Comparison of the effects of moist and dry conditions on the process of angiogenesis during dermal repair.
Relationship between joint space width and subchondral sclerosis in the osteoarthritic hand: a quantitative microfocal radiographic study.
A robust and accurate method for calculating the fractal signature of texture in macroradiographs of osteoarthritic knees.
Analysis of texture in macroradiographs of osteoarthritic knees using the fractal signature.
Comparison of clinical, radionuclide, and radiographic features of osteoarthritis of the hands.
Osteophytes in the osteoarthritic hand: their incidence, size, distribution, and progression.
Techetium 99m methylene diphosphonate bone scanning in osteoarthritic hands.
Quantitative microfocal radiographic assessment of progression in osteoarthritis of the hand.
