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Robert Flavell, MD, PhD
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Publications
Robert Flavell, MD, PhD's Publications
2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.
ACR-ACNM-ARS-SNMMI-SPR Practice Parameter for Treatment of Benign and Malignant Thyroid Disease With I-131 Sodium Iodide.
Development of 18F-labelled Zinc Biosensors and PET Imaging.
Effective imaging and treatment of Acute Myeloid Leukemia with radiotheranostics targeting the activated conformation of integrin-ßeta2.
Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy.
Evaluation of 134Ce/134La-PSMA-617 for PET Imaging and Auger Electron Therapy of Prostate Cancer.
Open-source implementation of X-nuclear sequences using the Pulseq framework.
PET Imaging Using 89Zr-Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention in Prostate Cancer.
Phase I, First-in-Human Study of FOR46 (FG-3246), an Immune-Modulating Antibody-Drug Conjugate Targeting CD46, in Patients With Metastatic Castration-Resistant Prostate Cancer.
Pre- or post-chemotherapy: effect on PSMA uptake.
Pretherapy Radiobiological Dosimetry Using Self-Calibrating Quantitative Hybrid Imaging for Metastatic Thyroid Cancer Treatment with 131I.
Selective treatment of acute myeloid leukemia targeting the activated conformation of integrin beta2 with [225Ac]Macropa-PEG4-7065.
18F-FDG Dedicated Breast PET Complementary to Breast MRI for Evaluating Early Response to Neoadjuvant Chemotherapy.
3D small-scale dosimetry and tumor control of 225Ac radiopharmaceuticals for prostate cancer.
68Ga-FAP-2286 PET of Solid Tumors: Biodistribution, Dosimetry, and Comparison with 18F-FDG.
A phase 1b dose escalation study of FOR46, a novel antibody-drug conjugate targeting a tumor-specific epitope of CD46, in combination with enzalutamide (Enza) in patients with metastatic castration resistant prostate cancer (mCRPC).
A Sparse Uncollimated ? Counter Network for In Vivo Dose Reconstruction in 225Ac-Based Targeted Alpha Therapy.
A Technique to Quantify Very Low Activities in Regions of Interest With a Collimatorless Detector.
Actinium-225 targeted alpha particle therapy for prostate cancer.
Bioorthogonal Radiolabeling of Azide-Modified Bacteria Using [18F]FB-sulfo-DBCO.
CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.
Comparative Uptake Patterns of Radioactive Iodine and [18F]-Fluorodeoxyglucose (FDG) in Metastatic Differentiated Thyroid Cancers.
Development of CD46 targeted alpha theranostics in prostate cancer using 134Ce/225Ac-Macropa-PEG4-YS5.
Enhanced Prostate-specific Membrane Antigen Targeting by Precision Control of DNA Scaffolded Nanoparticle Ligand Presentation.
Impact of Posttreatment SPECT/CT on Patient Management During 177Lu-PSMA-617 Radiopharmaceutical Therapy.
Millimeter-scale radioluminescent power for electronic sensors.
Pathologic outcome of incidentally detected tracer-avid lesions in 68Ga-PSMA-11 PET/CT for prostate cancer.
Peptidoglycan-Targeted [18F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection.
Prostate-Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer.
Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors.
Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection.
Beyond Anatomy: The Role of Molecular Imaging in the Evaluation of Low Back Pain.
CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment.
Chemoenzymatic syntheses of fluorine-18-labeled disaccharides from [ 18 F]FDG yield potent sensors of living bacteria in vivo.
Chemoenzymatic Syntheses of Fluorine-18-Labeled Disaccharides from [18F] FDG Yield Potent Sensors of Living Bacteria In Vivo.
Clinically Translatable Hyperpolarized 13C Bicarbonate pH Imaging Method for Use in Prostate Cancer.
Coded aperture and Compton imaging for the development of 225 Ac-based radiopharmaceuticals.
Covalent Proteins as Targeted Radionuclide Therapies Enhance Antitumor Effects.
Evaluating the Performance of Pathogen-Targeted Positron Emission Tomography Radiotracers in a Rat Model of Vertebral Discitis-Osteomyelitis.
Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225Ac α-Radiotherapeutics.
Imaging the Bacterial Cell Wall Using N-Acetyl Muramic Acid-Derived Positron Emission Tomography Radiotracers.
Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer.
Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.
O-04 StarPEG Nanocarriers for PSMA Targeted Radioligand Imaging and Therapy.
O-14 Evaluation of 134Ce/La pair as a PET imaging surrogate for 225Ac radiotherapeutics.
O-77 Molecular imaging and radiopharmaceutical therapy of Multiple Myeloma targeting CD46 using 89Zr and 225Ac-YS5.
P-171 StarPEG Nanocarriers for Prostate Cancer Imaging and Drug Delivery.
P-219 Fluorine-mediated desilylative Carbon-11 carboxylation of acylsilanes with [11C]CO2 for the radiosynthesis of [1-11C]a-keto acids.
P-288 Alpha particle therapy for the treatment of metastatic tumors of prostate cancer.
PSMA-Targeted Nanotheranostics for Imaging and Radiotherapy of Prostate Cancer.
Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy.
177Lu-PSMA Therapy.
Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma.
Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13 C,15 N2 ]urea + [1-13 C]pyruvate simultaneous perfusion and metabolic imaging.
Dosimetry in radionuclide therapy: the clinical role of measuring radiation dose.
First-in-human immunoPET imaging of HIV-1 infection using 89Zr-labeled VRC01 broadly neutralizing antibody.
Imaging joint infections using D-methyl-11C-methionine PET/MRI: initial experience in humans.
Imaging of solid tumors using 68Ga-FAP-2286.
Non-Iodine-Avid Disease Is Highly Prevalent in Distant Metastatic Differentiated Thyroid Cancer With Papillary Histology.
Nuclear imaging of bacterial infection: the state of the art and future directions.
O-08 Efficient chelation of 134Ce/La using the macrocyclic chelators DOTA and Macropa as potential PET imaging agents.
O-46 CD46 targeted, Actinium-225 labelled antibody for treatment of prostate cancer xenografts.
O-46 Treatment of prostate cancer xenografts with the targeted alpha-particle nanogenerator [225Ac]Ac-DOTA-YS5.
P-003 Influence of short PEG linkers on biodistribution of 225Ac-Macropa-YS5, an immunoconjugate for treating CD46 expressing cancer.
P-65 Cyclic [68Ga] and [18F]AlF-labeled peptides for specific detection of human angiotensin-converting enzyme 2.
Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers.
Retrospective study of the incidence of sarcoidosis-like reaction in patients treated with immunotherapy.
Abstract PS13-50: Relationship of dedicated breast PET and MRI features in breast cancer patients receiving neoadjuvant chemotherapy.
Authors' Reply: To the Letter to the Editor by Groheux et al.
Causes of False-Positive Radioactive Iodine Uptake in Patients with Differentiated Thyroid Cancer.
Cyclic 68Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2.
Deuterium Metabolic Imaging-Rediscovery of a Spectroscopic Tool.
Gastrointestinal Stromal Tumor Incidentally Detected on 18F-Fluciclovine PET/CT.
Imaging 6-Phosphogluconolactonase Activity in Brain Tumors In Vivo Using Hyperpolarized δ-[1-13C]gluconolactone.
Prostate cancer research in the 21st century; report from the 2021 Coffey-Holden prostate cancer academy meeting.
Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen.
Synthesis of N-trifluoromethyl amides from carboxylic acids.
TBMT-01. HYPERPOLARIZED d-[1-13C]GLUCONOLACTONE MONITORS TERT-INDUCED ELEVATION IN PENTOSE PHOSPHATE PATHWAY FLUX IN BRAIN TUMORS IN VIVO.
Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy.
68Ga-PSMA-11 PET/MRI: determining ideal acquisition times to reduce noise and increase image quality.
800 Impact of 68Ga-PSMA-11 PET on the management of biochemically recurrent prostate cancer in a prospective single-arm clinical trial.
An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.
Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.
Evaluation of primary breast cancers using dedicated breast PET and whole-body PET.
Factors Predicting Metastatic Disease in 68Ga-PSMA-11 PET-Positive Osseous Lesions in Prostate Cancer.
Failure of iodine uptake in microscopic pulmonary metastases after recombinant human thyroid-stimulating hormone stimulation.
Gallium-68 prostate-specific membrane antigen ([68Ga]Ga-PSMA-11) PET for imaging of thyroid cancer: a feasibility study.
High Accuracy of PSMA PET in Initial Staging of High-Risk Prostate Cancer.
Impact of 68Ga-PSMA-11 PET on the management of biochemically recurrent prostate cancer in a prospective single-arm clinical trial.
Impact of 68Ga-PSMA-11 PET on the Management of Recurrent Prostate Cancer in a Prospective Single-Arm Clinical Trial.
Management of Challenging Radioiodine Treatment Protocols: A Case Series and Review of the Literature.
Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET.
Molecular imaging of prostate cancer targeting CD46 using immunoPET.
Nuclear Imaging of Bacterial Infection: The State of the Art and Future Directions.
PET/CT in Surgical Planning for Head and Neck Cancer.
Preclinical SPECT and SPECT-CT in Oncology.
Quantitative and Qualitative Improvement of Low-Count [68Ga]Citrate and [90Y]Microspheres PET Image Reconstructions Using Block Sequential Regularized Expectation Maximization Algorithm.
Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers.
Small Molecule Sensors Targeting the Bacterial Cell Wall.
The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-11C-YJH08 PET.
Understanding Response to Immunotherapy Using Standard of Care and Experimental Imaging Approaches.
Use of 18F-FDG PET/CT as an Initial Staging Procedure for Stage II-III Breast Cancer: A Multicenter Value Analysis.
Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy.
Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer: A Prospective Single-Arm Clinical Trial.
CBMT-08. IN VIVO EVALUATION OF PENTOSE PHOSPHATE PATHWAY ACTIVITY IN ORTHOTOPIC GLIOMA USING HYPERPOLARIZED d-[1-13C]GLUCONOLACTONE.
Heterogeneous Uptake of 18F-FDG and 68Ga-PSMA-11 in Hepatocellular Carcinoma.
High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection.
Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer.
Incidentally Detected Oropharyngeal Squamous Cell Carcinoma on 18F-Fluciclovine PET/CT.
Intertumoral Heterogeneity of 18F-FDG and 68Ga-PSMA Uptake in Prostate Cancer Pulmonary Metastases.
Molecular Imaging of Renal Malignancy: A Review.
Single-Center Prospective Evaluation of 68Ga-PSMA-11 PET in Biochemical Recurrence of Prostate Cancer.
Spatiotemporal pH Heterogeneity as a Promoter of Cancer Progression and Therapeutic Resistance.
Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.
The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI.
Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging.
A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain.
Cardiac Fibroma: An Uncommon Cause of a Fixed Defect on Myocardial Perfusion Imaging.
Detection of Metastatic Meningioma to the Liver Using 68Ga-DOTA-Octreotate PET/CT.
Direct assessment of renal mitochondrial redox state using hyperpolarized 13 C-acetoacetate.
Discordant Findings on 18F-NaF and 99mTc-HDP Bone Scans in a Patient With ATTR Cardiac Amyloidosis.
Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes.
Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.
Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.
Scatter Artifact with Ga-68-PSMA-11 PET: Severity Reduced With Furosemide Diuresis and Improved Scatter Correction.
[11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism.
Abnormal 18F-FDG and 82Rb PET Findings in Chagas Heart Disease.
Abnormal pulmonary 18F-florbetapir uptake in a patient evaluated for recurrent cardiac amyloidosis following orthotopic heart transplant.
Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging.
Effect of Time-of-Flight and Regularized Reconstructions on Quantitative Measurements and Qualitative Assessments in Newly Diagnosed Prostate Cancer With 18F-Fluorocholine Dual Time Point PET/MRI.
Exploring Metabolism In Vivo Using Endogenous 11C Metabolic Tracers.
Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.
Incidental Detection of Head and Neck Squamous Cell Carcinoma on 68Ga-PSMA-11 PET/CT.
Somatostatin receptor PET/MRI for the evaluation of neuroendocrine tumors.
A reactivity-based [18F]FDG probe for in vivo formaldehyde imaging using positron emission tomography.
Detecting Pulmonary Nodules in Lung Cancer Patients Using Whole Body FDG PET/CT, High-resolution Lung Reformat of FDG PET/CT, or Diagnostic Breath Hold Chest CT.
Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.
Malignancies with Low Fluorodeoxyglucose Uptake at PET/CT: Pitfalls and Prognostic Importance: Resident and Fellow Education Feature.
Recent Developments in Combined PET/MRI.
[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.
Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI.
Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.
Predictors of pathologic outcome of focal FDG uptake in the parotid gland identified on whole-body FDG PET imaging.
Abnormal findings on multiparametric prostate magnetic resonance imaging predict subsequent biopsy upgrade in patients with low risk prostate cancer managed with active surveillance.
The incidence of pulmonary embolism and associated FDG-PET findings in IV contrast-enhanced PET/CT.
ChemInform Abstract: Expressed Protein Ligation (EPL) in the Study of Signal Transduction, Ion Conduction, and Chromatin Biology.
Expressed protein ligation (EPL) in the study of signal transduction, ion conduction, and chromatin biology.
PET imaging of leptin biodistribution and metabolism in rodents and primates.
Site-specific (18)F-labeling of the protein hormone leptin using a general two-step ligation procedure.
Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor.
