The Noworolski laboratory has established methods to evaluate ectopic fat stores using MRI and to assess fat, inflammation and fibrosis in the liver to characterize disease and to assess interventions. With collaborators, we have demonstrated effects of short-term dietary changes on de novo lipogenesis and lipid storage in the livers of normal subjects and subjects, including children, with obesity and/or metabolic syndrome. Through traditional image processing and via convolutional neural network algorithms, we have automated the analyses of some of our more established metrics of fatty liver disease. We are pursuing novel imaging techniques to aid in further characterizing metabolic health.
References:
- Noworolski SM, Tien PC, Merriman R. Vigneron DB, Qayyum A. Respiratory Motion-Corrected Proton Magnetic Resonance Spectroscopy of the Liver. Magn Reson Im. 27(4): 570-576. 2009. (PMCID: PMC2917604).
- Noworolski SM, Lam M, Merriman RB, Ferrell L, Qayyum A. Estimation of Steatosis with MRS and MRI: Validation with Histology is Confounded by Differences in Methodology. Radiology. 264:88-96. 2012. (PMCID: 3380413).
- Schwarz JM. Noworolski SM, Wen MJ, Dyachenko A, Prior JL, Weinberg ME, Herraiz LA, Bergeron N, Bersot TP, Rao MN, Schambelan M, and Mulligan K. Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat. J Clin Endo Metab. 2015 100(6):2434-2442. DOI: http://dx.doi.org/10.1210/jc.2014-3678. (PMCID: PMC4454806).
- ¥¥Schwarz JM, Noworolski SM, Erkin-Cakmak A, Korn NJ, Wen MJ, Tai VW, Jones GM, Palii S, Velasco-Alin M, Pan K, Patterson BW, Gugliucci A, Lustig RH, Mulligan K. Effects of dietary fructose restriction on liver fat, de novo lipogenesis, and insulin kinetics in children with obesity. Gastroenterology. 153(3): 743-752. 2017. doi: 10.1053/j.gastro.2017.05.043. (PMCID PMC5813289).
¥¥ Schwarz and Noworolski contributed equally to this work and this is stated in the manuscript. Lustig and Mulligan contributed equally to this work and this is stated in the manuscript.