Multiparametric MRI of Prostate Cancer – Correlations with Histopathology

The Noworolski Lab has a long history of establishing the mpMRI signatures of cancerous and various benign tissues, with detailed correlation with histopathology. In recent years, this has been focused on the prostate – for both identifying cancer and for distinguishing aggressive prostate cancer from indolent cancer. Based upon these analyses, we have generated cancer risk maps and aggressive cancer risk maps.

References:
  1. Starobinets O, Simko J, Kuchinsky K, Kornak J, Carroll PR, Greene KL, Kurhanewicz J, Noworolski SM. Characterization and Stratification of Prostate Lesions Based on Comprehensive Multiparametric MR Imaging Using Detailed Whole Mount Histopathology as a Reference Standard. NMR Biomed. 2017; 30(12). DOI: 10.1002/nbm.3796. (PMCID PMC9592076).
  2. Gibbons M, Starobinets O, Simko JP, Kurhanewicz J, Carroll PR, Noworolski SM. Identification of Prostate Cancer Using Multiparametric MR Imaging Characteristics of Prostate Tissues Referenced to Whole Mount Histopathology. Magn Reson Imaging. 2022 Jan;85:251-261. Doi: 10.1016/j.mri.2021.10.008. PMCID: PMC9931199.
  3. Gibbons M, Simko JP, Carroll PR, Noworolski SM. Prostate Cancer Lesion Detection, Volume Quantification and High-grade Cancer Differentiation using Cancer Risk Maps Derived from Multiparametric MRI with Histopathology as the Reference Standard. Magn Reson Imaging. 2023. https://doi.org/10.1016/j.mri.2023.01.006