We investigated the effects of weight loss and weight gain on hip and knee radiographic changes, pain, and joint replacement over 4 years in the Osteoarthritis Initiative Cohort. Our results of this large, longitudinal study (n = 2,752 with 4-year follow-up) suggested that weight loss may protect against, and weight gain may exacerbate, radiographic and symptomatic knee OA, while weight change (at a 5% threshold) does not have significant effects on hip OA.
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Effects of Weight Change on Knee and Hip Radiographic Measurements and Pain Over Four Years: Data From the Osteoarthritis Initiative. Joseph GB, McCulloch CE, Nevitt MC, Lynch J, Lane NE, Link TM. Arthritis Care Res (Hoboken). 2023 Apr;75(4):860-868. doi: 10.1002/acr.24875. Epub 2022 Nov 18.
Associations between weight change, knee subcutaneous fat and cartilage thickness in overweight and obese individuals: 4-Year data from the osteoarthritis initiative. Joseph GB, Takakusagi M, Arcilla G, Lynch JA, Pedoia V, Majumdar S, Lane NE, Nevitt MC, McCulloch CE, Link TM. Osteoarthritis Cartilage. 2023 Nov;31(11):1515-1523. doi: 10.1016/j.joca.2023.07.011. Epub 2023 Aug
The effect of interactions between BMI and sustained depressive symptoms on knee osteoarthritis over 4 years: data from the osteoarthritis initiative. Joseph GB, McCulloch CE, Nevitt MC, Lynch J, Lane NE, Pedoia V, Majumdar S, Link TM. BMC Musculoskelet Disord. 2023 Jan 12;24(1):27. doi: 10.1186/s12891-023-06132-3.