Analyzing the complex pathophysiology of knee and hip joint degeneration and impact of gait biomechanics in hip OA patients (KICK-Study)
In this study, we are focusing on the hip-knee joint bone and cartilage interaction and the association of bone shape with incident and severe OA condition and investigate the difference in loading pattern using in-vivo motion analysis tool. Our goal is to evaluate the changes in the bilateral bone shape asymmetry of hip and knee joint and understand the mediation effects of gait biomechanics. This is a longitudinal study investigating 100 people with unilateral hip OA condition.
Related publications
- Thahakoya R et al. Evaluating the relationship of proximal bone shape asymmetry with cartilage health and biomechanics in patients with hip OA. In Proceedings of the 31st Annual Meeting of ISMRM, Toronto, Ontario, Canada, 2023. 4373
- Bhattacharjee R, Luitjens J, Han M, Thahakoya R, Roach K, Souza R, Pedoia V, Majumdar S. Preserved patellar cartilage at the expense of anterior femoral cartilage damage in Hip Osteoarthritis: An Inter-Limb Inter-Joint qMRI analysis. In Proceedings of the 31st Annual Meeting of ISMRM, Toronto, Ontario, Canada, 2023. 2454.
Project members at UCSF
Rafeek Thahakoya, Rupsa Bhattacharjee, Eric Hammond, Misung Han, Emma Bahroos, Valentina Pedoia, Richard Souza, Sharmila Majumdar
Funding number
NIHR01AR069006
A) Bone shape Modeling B) Cartilage T1rho/T2 Mapping C) Functional Performance Testing