Simultaneous Imaging of Tissue Biochemistry and Metabolism Associated with Biomechanics in Patellofemoral Joint Osteoarthritis (PFJOA)
In this prospective study, we are aiming for a deeper understanding of the mechanics underlying bone and cartilage interactions (via simultaneous bilateral PET-MRI) and the mediation role of gait biomechanics and bone morphology for human subjects with isolated patellofemoral joint osteoarthritis (PFJ-OA). Our overall goal is to: (i) identify cross-sectional and longitudinal local patterns of cartilage and bone interactions unique to PFJOA, and (ii) determine the mediation effects of gait biomechanics and bone morphology on PFJOA progression. We are conducting a longitudinal cohort study investigating 100 people with isolated PFJOA. Simultaneous PET-MRI and gait biomechanics are being collected for all subjects at baseline and 2-year follow-up.
Related publications
- Tibrewala R, Pedoia V, Bucknor M, Majumdar S. Principal Component Analysis of Simultaneous PET-MRI Reveals Patterns of Bone-Cartilage Interactions in Osteoarthritis. Journal of magnetic resonance imaging: JMRI. 2020. Epub 2020/03/25. doi: 10.1002/jmri.27146. PubMed PMID: 32207870.
- Bhattacharjee R, Hammond C, Roach K, Bahroos E, Souza R, Majumdar S, Pedoia V, Towards the understanding of the role of Functional strength markers in Cartilage-Bone Cross Talk: a PET/MRI study in isolated PFJOA patients, ISMRM 2023, Toronto, Canada, (Proc. Intl. Soc. Mag. Reson. Med. 31(2023), Page Nu-0101)
Project members at UCSF
Rupsa Bhattacharjee, Valentina Pedoia, Richard Souza, Sharmila Majumdar, Eric Hammond, Laura Chen, Joshua Johnson, Misung Han, Emma Bahroos
Funding number
NIHR56AR079647
Cartilage T2/T1rho and Bone SUV interactions in PFJ
Example case of an adult male of 51 years of age, 1.8 meters height and 81.66 kgs of weight falling in an almost healthy BMI range.