Quantitative MRI to Evaluate Rotator Cuff Tendon Degeneration
The primary objectives of this research project are to develop quantitative MRI techniques to assess the quality of tendons and muscles within the rotator cuff. Rotator cuff tears are a common source of pain and disability in the upper extremity. While rotator cuff surgeries are frequently performed, the occurrence of tendon retears poses a significant challenge. We believe the development of accurate quantification methods for both rotator cuff tendons and muscles help to determine optimal treatment strategies. In particular, we are interested in developing ultrashort-echo time MRI techniques for T2* quantification as well as magnetization-transfer quantification.
Related publications
Han M, Larson PE, Link TM, Lansdown DA, Feeley BT, Majumdar S. Quantitative Ultrashort Echo-Time MRI to Assess In Vivo Rotator Cuff Tendon Degeneration. In: Proc the Annual Meeting ISMRM&SMRT, Toronto, ON, Canada, 2023. p. 5113.
Project members at UCSF
Misung Han, Erin Argentieri, Peder Larson, Thomas Link, Drew Lansdown, Brian Feeley, Sharmila Majumdar, Zehra Akkaya, Jocelyn Carpio, Isabelle Remick
Funding number
NIH/NIAMS K01AR075895 (July 2020-June 2025), CTSI RAP grant (July 2021-June 2022)
Principal Investigator
Misung Han (Mentors: Sharmila Majumdar, Brian Feeley, and Peder Larson)
Supraspinatus Tendon Quantification: Comparison of quantified T2* and macromolecule fractions in the supraspinatus tendon between a healthy subject and a patient with a tear based on UTE techniques.